Analgin, solution


Metabolized to form the main metabolite 4N-methylaminoantipyrine (MAA) and other metabolites - 4N-aminoantipyrine (AA), 4N-acetylaminoantipyrine (AAA) and 4N-formylaminoantipyrine (FAA).

Metabolites AAA and PAA do not have pharmacological activity. All metabolites have nonlinear pharmacokinetics; with short-term use, the accumulation of metabolites does not play a big role. Plasma protein binding is 58% for MAA, 48% for AA, 18% for FAA, and 14% for AAA.

Metamizole sodium crosses the placenta. Metamizole sodium metabolites pass into breast milk. Approximately 96% is excreted by the kidneys in the form of metabolites. After intravenous administration, the half-life of metamizole sodium is 14 minutes.

When high doses of metamizole sodium are administered, the kidneys may excrete a metabolite, rubazonic acid, which can turn urine red.


In elderly patients, the area under the concentration-time curve increases by 2-3 times.

Liver dysfunction

In patients with liver cirrhosis, the half-life of MAA and FAA with a single dose of the drug increases approximately 3 times, the half-life of AA and AAA does not change. In such patients, high doses should be avoided.

Renal dysfunction

In renal failure, the rate of elimination of some metabolites (AAA and FAA) is reduced. In such patients, high doses should be avoided.


- hypersensitivity to pyrazolone derivatives (propyphenazone, phenazone or phenylbutazone);

- bronchial asthma induced by taking acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs);

— bronchial obstruction, rhinitis, urticaria, provoked by taking acetylsalicylic acid or other NSAIDs (including a history);

— condition after coronary artery bypass grafting;

- inhibition of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia);

- acute renal or liver failure;

- acute intermittent hepatic porphyria;

- confirmed hyperkalemia;

- erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal bleeding, inflammatory bowel diseases;

- anemia, leukopenia;

- hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;

— pregnancy (I and III trimester), breastfeeding period;

— infancy (up to 3 months with body weight less than 5 kg);

- for intravenous administration - children up to 12 months (body weight up to 9 kg).


Arterial hypotension (systolic blood pressure (BP) below 100 mm Hg); decrease in circulating blood volume (CBV); hemodynamic instability (myocardial infarction, multiple trauma, incipient shock); incipient heart failure; high fever (increased risk of a sharp decrease in blood pressure).

Diseases in which a significant decrease in blood pressure may be of increased danger (severe coronary heart disease, stenosis of cerebral arteries).

Chronic alcohol abuse.

Bronchial asthma, especially in combination with concomitant polypous rhinosinusitis; chronic urticaria and other types of atopy (allergic diseases, in the development of which a significant role is played by a hereditary predisposition to sensitization: hay fever, allergic rhinitis, etc.) (increased risk of developing anaphylactic/anaphylactoid reactions).

Alcohol intolerance (reaction to even small amounts of certain alcoholic beverages in the form of itching, watery eyes and severe redness of the face) (increased risk of developing anaphylactic/anaphylactoid reactions).

Intolerance or hypersensitivity to dyes (eg, tartrazine) or preservatives (eg, benzoate) (increased risk of anaphylactic/anaphylactoid reactions).

Severe impairment of liver and kidney function (the use of low doses is recommended due to the possibility of slowing the rate of excretion of metamizole sodium).

Pregnancy (II trimester).

Use during pregnancy and breastfeeding


Metamizole sodium penetrates the placental barrier. Data on the use of metamizole sodium during pregnancy are limited. Since there are no adequate data on use in humans, metamizole sodium should not be used in the first trimester of pregnancy; in the second trimester of pregnancy, the drug can be used if the expected benefit to the mother outweighs the potential risk to the fetus. Despite the fact that metamizole sodium weakly inhibits the synthesis of prostaglandins, the possibility of premature (intrauterine) closure of the ductus arteriosus, as well as perinatal complications caused by impaired platelet aggregation in the mother or newborn cannot be excluded. In this regard, metamizole sodium is contraindicated in the third trimester of pregnancy.

Breastfeeding period

Metamizole sodium metabolites pass into breast milk, therefore, when using the drug, as well as within 48 hours after taking the last dose, breastfeeding should be stopped.

Pharmacological action of the drug

The drug works thanks to metamizole sodium. The active substance belongs to the group of pyrazolones. Metamizole sodium is a non-steroidal substance that relieves inflammation, reduces the production of prostaglandins (inflammatory mediators) in the body, increases the pain sensitivity threshold of the thalamus, thereby providing an analgesic effect. The drug also increases the release of heat by the body, which leads to a decrease in temperature.

Its ability to eliminate inflammation is less than that of similar non-steroidal drugs, but the antipyretic effect is stronger. It does not cause irritation on the mucous membrane of the stomach and intestines, and does not affect water-salt metabolism. The drug is an antispasmodic that affects the smooth muscles of the urinary and biliary tracts. The effect is noticeable after 30 minutes, the maximum concentration of the substance in the blood plasma is observed after 1.5-2 hours. It is easily absorbed by the stomach and can be dissolved, which allows it to be used for inhalation and injection.

special instructions

In patients receiving cytotoxic drugs, as well as in children under 5 years of age, the use of metamizole sodium should only be carried out under medical supervision.

Anaphylactic/anaphylactoid reactions

When choosing a method of drug administration, it should be taken into account that parenteral administration is associated with a higher risk of anaphylactic/anaphylactoid reactions. An increased risk of developing hypersensitivity reactions to metamizole sodium may be due to the following conditions: - analgesic bronchial asthma, especially with concomitant polypous rhinosinusitis; - chronic urticaria; - alcohol intolerance (increased sensitivity to alcohol), against the background of which, even when taking a small amount of certain alcoholic beverages, patients experience sneezing, lacrimation and severe redness of the face.

Alcohol intolerance may indicate previously unidentified aspirin asthma syndrome; - intolerance or hypersensitivity to dyes (for example, tartrazine) or preservatives (for example, benzoate).

Before using metamizole sodium, it is necessary to conduct a thorough survey of the patient in order to determine medical history. If the risk of developing anaphylactic reactions is identified, use is possible only after a thorough assessment of the ratio of the expected benefit to the possible risk of using metamizole sodium.

In the case of using metamizole sodium in such patients, it is necessary to ensure the availability of funds to provide them with emergency assistance in the event of the development of anaphylactic/anaphylactoid reactions and strict medical monitoring of their condition.

Metamizole sodium should be used with caution in patients with asthma or atopy.

Patients who experience anaphylactoid reactions when using metamizole sodium are also at risk of developing them when using other non-narcotic analgesics/NSAIDs.

Patients who experience anaphylactic or other immune-mediated reactions (eg, agranulocytosis) in response to the use of metamizole sodium are also at risk of developing them when using other pyrazolones and pyrazolidines.

Severe skin reactions

Life-threatening skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), have been described with the use of metamizole sodium.

If symptoms of SJS and TEN appear, including a progressive skin rash, often with blisters or lesions of the mucous membrane, treatment with metamizole sodium should be stopped immediately and should not be continued in this category of patients. Patients should be aware of the symptoms of these skin reactions.

They should be carefully monitored for skin reactions, especially during the first days of treatment.


With long-term use (more than 7 days), it is necessary to monitor the peripheral blood picture. With the use of metamizole sodium, agranulocytosis may develop. It occurs very rarely, lasts at least a week, is not dose-dependent, can be severe, life-threatening and, in some cases, fatal. Therefore, if you identify symptoms such as an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, erosive and ulcerative lesions of the oral cavity, vaginitis or proctitis, a decrease in the number of neutrophils in the peripheral blood less than 1500/mm3, you must immediately contact See your doctor and stop taking the drug.


If pancytopenia develops, use of the drug should be stopped immediately, and complete blood count indicators should also be monitored until they return to normal. All patients should be aware that pathological changes in the blood during the use of metamizole sodium may be accompanied by the appearance of symptoms such as general malaise, infections, persistent fever, hematoma formation, bleeding, pale skin, which requires immediate consultation with a doctor.

Isolated hypotensive reactions

Metamizole sodium may cause isolated hypotensive reactions, which may be dose-dependent. The risk of reactions is increased with previous arterial hypotension, decreased blood volume or dehydration, unstable hemodynamics or acute circulatory disorders (for example, in patients with myocardial infarction or trauma), in patients with fever. Such patients should be assessed in detail and closely monitored.

In order to reduce the risk of developing hypotensive reactions, preventive measures (hemodynamic stabilization) may be required. In patients in whom blood pressure reduction should be avoided at all costs (for example, with severe coronary artery disease or significant cerebral artery stenosis), the drug can be used with careful monitoring of hemodynamic parameters.

Abdominal pain

It is unacceptable to use metamizole sodium to relieve acute abdominal pain (until the cause is determined).

Liver and kidney dysfunction

In patients with impaired liver or kidney function, it is recommended to avoid the use of metamizole sodium in high doses due to a decrease in its elimination rate. The drug contains sodium, which should be taken into account by people on a low sodium diet.

Rules for administering the drug

Intravenous administration should be carried out very slowly (no more than 1 ml per minute) in order to quickly stop the drug at the first signs of anaphylactic/anaphylactoid reactions and/or to minimize the occurrence of isolated hypotensive reactions.

For intramuscular administration, it is necessary to use a long intramuscular needle.

Impact on the ability to drive vehicles and machinery

Considering the profile of adverse reactions when using metamizole sodium, caution should be exercised when driving vehicles, machinery, as well as when performing work that requires increased concentration and speed of psychomotor reactions.

Directions for use and doses

Intravenously, intramuscularly deep into the muscle.

Parenteral administration of the drug is indicated only if it is impossible to take it orally. Before administration, it is recommended to warm the drug to body temperature.

Adults and adolescents over 15 years of age: 1.0-2.0 ml (500 mg/ml) of metamizole solution (intramuscular or intravenous) is recommended as a single dose. The maximum daily dose is 2000 mg, divided into 2-3 administrations per day. The maximum daily dose is 1000 mg.

For children aged 3-11 months (body weight more than 5 kg to 9 kg), the drug is administered only intramuscularly at a dose of 50-100 mg per 10 kg of body weight (0.1-0.2 ml of a 500 mg/ml solution). A single dose can be divided into 2-3 injections.

The following table contains recommended doses of the drug.

Age (body weight) Dose
Children 3-11 months (over 5 kg to 8 kg) Intramuscular administration only!!! 0.1-0.2 ml (corresponding to 50-100 mg of metamizole)
Children 1-3 years old (approx. 9-15 kg) 0.2-0.5 ml (corresponding to 100-250 mg of metamizole)
Children 4-6 years old (approx. 16-23 kg) 0.3-0.8 ml (corresponding to 150-400 mg of metamizole)
Children 7-9 years old (about 24-30 kg) 0.4-1.0 ml (corresponding to 200-500 mg of metamizole)
Children 10-12 years old (approx. 31-45 kg)0.5-1.0 ml (corresponding to 250-500 mg of metamizole)
Children 13-14 years old (approx. 46-53 kg) 0.8-1.8 ml (corresponding to 400-900 mg of metamizole)
Adults and adolescents over 15 years of age (weighing more than 53 kg) 1.0-2.0 ml (corresponding to 500-1000 mg of metamizole)

Intravenous administration should be carried out very slowly (infusion rate no more than 1 ml/min) with the patient lying down, under blood pressure control. At the first signs of the development of anaphylactic/anaphylactoid reactions, it is necessary to stop administering the drug.

Since the hypotensive reactions are dose-dependent, parenteral administration of a dose of 1000 mg of metamizole should be carried out with extreme caution. If the drug is administered too quickly, a critical drop in blood pressure and shock may occur.

Elderly patients need to use lower dosages due to a possible decrease in the excretion of metamizole metabolites from the body. Patients in serious condition and with impaired creatinine clearance should use smaller doses due to a possible decrease in the excretion of metamizole metabolites from the body.

In patients with impaired liver and kidney function, the rate of elimination of the drug is slowed down, so repeated use of the drug should be avoided. There is no experience with long-term use. For short-term therapy, no dose adjustment is required.

When used as an analgesic, the duration of therapy is 1-5 days. When used as an antipyretic – 1-3 days.


There is less metamizole sodium in preparations for children. For children, it is more convenient to use suppositories, dosage from 100 to 250 mg. For children aged 3 months to one year, a weak dosage is divided into two doses. For children over one year old, you can already use the full dose of 100 mg. A child aged 3 to 7 years should already receive 1-2 suppositories of 200 mg. At 8-14 years of age, use up to 2 suppositories of the maximum dosage once twice a day.

The dosage of Analgin for children depends on age. If it is necessary to bring down a strong fever, diphenhydramine, papaverine and no-shpu are added to analgin. The dosage of tablets depends on age. A child from 2 to 3 years old should not receive more than 100 mg at a time, from 4 to 5 years old a dosage of 100-200 mg is possible, from 6 to 7 years old the maximum dose is 200 mg, from 8 to 14 years old - 300 mg. Tablets are given no more than 3 times a day.

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This form is not recommended for children. The tablets irritate the stomach and cause pain. Depending on age, the following dosage is acceptable:

  • from 2 to 3 years – no more than 50-100 mg per dose;
  • from 3 to 5 years – 100-200 mg per dose;
  • 6-7 years – 200 mg;
  • over 7 years – 300 mg.


Injecting Analgin intramuscularly will quickly bring down a high fever. The speed and force of the injection often saves the situation when the temperature reaches critical levels. The dose of metamizole should be calculated by the doctor taking into account body weight and age. Prescribe 10 mg of solution per 1 kg of weight. Analgin and Papaverine with Diphenhydramine - 0.1 ml each (up to one year of age). Plus 0.1-0.2 ml for every year of life. All medications must be taken into one syringe.


The form is suitable for use by children. Administered rectally. One suppository contains 200 mg of metamizole. It is worth calculating the dosage of an antipyretic drug depending on the age of the child:

  • from 6 months to a year – half a candle;
  • from one year to 3 years – 1 rectal suppository;
  • from 3 to 7 years – 400 mg per day;
  • from 7 years – 600 mg per day.


This procedure will instantly relieve the child’s condition. An enema helps increase the absorption of the drug in the lower intestines. Any medicine that enters the body this way will act instantly. For an enema with analgin, 20-30 ml of solution is enough. Half a tablet is enough for this volume. It is ground into powder and then dissolved. The water used is warm.

Side effect

Adverse reactions are classified as follows according to the World Health Organization (WHO) classification: very common (>1/10), common (>1/100 to <1/10), uncommon (>1/1000 to <1/100), rare (>1/10000 to <1/1000), very rare (up to <1/10000) and frequency unknown (cannot be estimated from available data).

Immune system disorders

Rarely: anaphylactic or anaphylactoid reactions.

Very rare: analgesic bronchial asthma.

Frequency unknown: anaphylactic shock.

Metamizole sodium may cause anaphylactic or anaphylactoid reactions, which in very rare cases can be severe and life-threatening. They can occur even if metamizole sodium has been previously used many times without any complications. Such drug reactions may develop immediately or some time after using metamizole sodium, usually within one hour. In milder cases, reactions manifest themselves in the form of skin and mucous membrane symptoms (itching, burning, flushing, urticaria, swelling); shortness of breath or patient complaints of gastrointestinal symptoms. In severe cases, they develop into generalized urticaria, severe angioedema (especially involving the larynx), severe bronchospasm, cardiac arrhythmias, a sharp decrease in blood pressure (which is sometimes preceded by an increase in blood pressure) and the development of circulatory shock.

In persons with analgesic bronchial asthma syndrome and intolerance to analgesic drugs, these reactions usually manifest themselves in the form of attacks of bronchial asthma.

From the blood and lymphatic system

Rarely: leukopenia.

Very rare: agranulocytosis (including fatal cases), thrombocytopenia.

Frequency unknown: aplastic anemia, pancytopenia (including fatal cases).

These reactions are immunological and can occur even if metamizole sodium has been previously used many times without any complications. Typical symptoms of agranulocytosis are lesions of the mucous membranes (oral cavity and pharynx, anorectal area, genital organs), sore throat, fever. However, when antibiotics are used, these phenomena may be mild. Sometimes, but not always, there is a slight enlargement of the lymph nodes or spleen. The erythrocyte sedimentation rate increases significantly, the content of granulocytes is sharply reduced or not determined. As a rule, hemoglobin, red blood cells and platelets remain normal, but deviations may occur. Typical symptoms of thrombocytopenia are an increased tendency to bleeding and the appearance of petechiae on the skin and mucous membranes.

If there is an unexpected deterioration in the general condition, the fever does not go away or ulcerations appear on the mucous membranes, especially the oral cavity, nose, and larynx, treatment tactics involve immediate discontinuation of the drug without waiting for the results of laboratory tests.

If pancytopenia develops, metamizole sodium should be discontinued and a complete blood count should be monitored until its values ​​return to normal (see section “Special Instructions”).

Heart disorders

Frequency unknown: Kounis syndrome (allergic coronary syndrome, manifested by clinical and laboratory signs of angina caused by inflammatory mediators).

Vascular disorders

Uncommon: isolated decrease in blood pressure.

An isolated transient decrease in blood pressure is possible (possibly pharmacologically caused, and not accompanied by other manifestations of anaphylactic/anaphylactoid reactions).

Rarely: a sharp pronounced decrease in blood pressure.

With fever, a dose-dependent sharp decrease in blood pressure without other signs of a hypersensitivity reaction is also possible.

Skin and subcutaneous tissue disorders

Uncommon: fixed drug dermatitis.

Rarely: skin rash.

Frequency unknown: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the kidneys and urinary tract

Very rare: renal dysfunction.

Frequency unknown: interstitial nephritis.

In very rare cases, patients with impaired renal function may experience an acute deterioration in renal function (acute renal failure), in some cases with oliguria, anuria, proteinuria.

General disorders

Uncommon: urine may turn red due to the presence of a metabolite in the urine - rubazonic acid.


Symptoms: nausea, vomiting, abdominal pain, decreased renal function/acute renal failure with oliguria (for example, due to the development of interstitial nephritis), less common central nervous system symptoms (dizziness, drowsiness, tinnitus, delirium, impaired consciousness, convulsions, coma) and a sharp decrease in blood pressure (sometimes progressing to shock), as well as heart rhythm disturbances (tachycardia), hypothermia, shortness of breath, acute agranulocytosis, hemorrhagic syndrome, paralysis of the respiratory muscles. After high doses, renal excretion of a non-toxic metabolite (rubazonic acid) may cause urine to turn red.

Treatment: There is no specific antidote. In case of overdose, forced diuresis is indicated. The main metabolite (4N-methylaminoantipyrine) can be eliminated by hemodialysis, hemofiltration, hemoperfusion or plasma filtration. With the development of convulsive syndrome, intravenous administration of diazepam and fast-acting barbiturates is indicated.

Interaction with other drugs

With cyclosporine: with simultaneous use, a decrease in the concentration of cyclosporine in the blood may be observed, therefore, when they are used together, monitoring of its concentration in the blood is required.

With other non-narcotic analgesics: simultaneous use of metamizole sodium can lead to mutual enhancement of toxic effects.

With tricyclic antidepressants, oral contraceptives, allopurinol: the drugs disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

With barbiturates, phenylbutazone and other inducers of microsomal liver enzymes: drugs weaken the effect of metamizole sodium.

With sedatives and tranquilizers: drugs enhance the analgesic effect of metamizole sodium. Concomitant use with chlorpromazine or other phenothiazine derivatives can lead to the development of severe hypothermia.

With drugs that are highly bound to plasma proteins (oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids (GCS) and indomethacin): metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin from its connection with plasma proteins, increases their activity .

With myelotoxic drugs: drugs increase the manifestations of hematotoxicity of metamizole sodium.

With methotrexate: simultaneous use of metamizole sodium with methotrexate may enhance the hematotoxic effect of methotrexate, especially in elderly patients. It is recommended to avoid simultaneous use.

With thiamazole and sarcolysine: the risk of developing leukopenia increases.

With radiocontrast agents, colloidal blood substitutes and penicillin: due to the increased risk of anaphylactic/anaphylactoid reactions, they should not be used in conjunction with metamizole sodium.

With codeine, propranolol, H2-histamine receptor blockers: drugs enhance the effect of metamizole sodium.

With acetylsalicylic acid: with simultaneous use, metamizole sodium can reduce the effect of acetylsalicylic acid on platelet aggregation. This combination should be used with caution in patients taking low doses of acetylsalicylic acid as an antiplatelet agent.

With bupropion: Metamizole sodium may reduce the concentration of bupropion in the blood, which should be taken into account when using them simultaneously.

Due to the high probability of pharmaceutical incompatibility, metamizole sodium should not be mixed with other drugs in the same syringe.

Combination with medications

It is important to correctly combine Analgin with other medications. Thus, the combination of metamizole sodium with analgesics from other groups increases toxicity and increases the risk of side effects. It is prohibited to use it together with antidepressants and allopurinol. While taking sedatives, the effect of Analgin is enhanced.

The drug enhances the effect of hormonal drugs, anticoagulants and hypoglycemic agents. To lower the temperature, it is combined with No-shpa and Suprastin, Papaverine, Diphenhydramine.

It is forbidden to use Analgin together with paracetamol in children; this combination can negatively affect the liver and leads to severe hypothermia and a decrease in blood pressure, even collapse.

Alena Paretskaya, pediatrician, medical columnist

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