Terzhinan for the treatment of thrush: pros and cons

Release form, composition and packaging

Excipients:
wheat starch, lactose monohydrate, colloidal silicon dioxide, magnesium stearate, sodium carboxymethyl starch.

What is Terzhinan

This is a combined topical drug used in gynecology. It has antibacterial, antiprotozoal, antifungal and anti-inflammatory properties. Four substances included in the composition determine the effect of the medication:

1. Ternidazole is a drug that acts against fungus, protozoa, and gram-negative bacteria.
2. Neomycin is an antibiotic that is active against gram-positive and gram-negative bacteria.
3. Nystatin is an antibiotic whose action is aimed at yeast-like fungi.
4. Prednisone is a hormone that reduces inflammation, swelling, and allergies.

Does not change the acid-base balance and integrity of the mucous membrane. This is necessary for the life and growth of normal vaginal microflora; in an acidic environment, lactobacilli suppress the growth of pathogenic microorganisms.

Terzhinan during breastfeeding is prescribed by a doctor after examining the patient, laboratory tests, and diagnosis. The prescription is justified if the benefits of treatment are greater than the negative effects on the infant.

Indications for use of the drug

The drug is prescribed for diseases that are caused by pathological flora that are sensitive to the drug:

• vaginitis of various origins;
• trichomoniasis;
• thrush caused by yeast-like fungi.

The drug is used not only for treatment, but also for the prevention of infections before:

• surgeries on the genitals;
• childbirth, termination of pregnancy;
• installation of an intrauterine device;
• endoscopic examination of the genital organs;
• cauterization of the cervix.

Terzhinan is used both for diseases of the female genital organs and for their prevention before any surgical interventions.

pros

The positive aspects of the medicine include the following:

1. Ease of use: every day at night, sleep - the medicine works.
2. Local action, not absorbed into the bloodstream. Safe for the child and low toxic for the mother.
3. Allowed during natural feeding , in the second and third trimester of pregnancy.
4. Wide spectrum of action, including use for thrush.
5. Do not stop taking it during discharge after childbirth and menstruation, since the effect of the medicine does not decrease.
6. Does not inhibit the vital activity of normal microflora, which protects against diseases.
7. It acts quickly, the result is noticeable already at the first doses.
8. Can be purchased without a prescription at the pharmacy.

Minuses

Among the negative points noted:

1. High price. There are candles with a similar effect, but much cheaper.
2. It is necessary to soak the tablet under water for half a minute.
3. After administration, you need to lie down for a quarter of an hour.
4. During the day, the medicine leaks and stains your underwear.
5. Causes discomfort in the lower abdomen and genitals.

pharmachologic effect

Combined drug for local use in gynecology. The effect of the drug is due to the properties of its constituent components.

Ternidazole, an imidazole derivative, has a trichomonacid effect and is also active against

anaerobic bacteria, in particular Gardnerella spp.

Neomycin sulfate is a broad-spectrum antibiotic from the aminoglycoside group.

Nystatin is an antifungal antibiotic from the group of polyenes, highly active against

fungi of the genus Candida.

Prednisolone is a glucocorticoid that has a pronounced anti-inflammatory effect.

The composition of the excipient ensures the integrity of the vaginal mucosa and constant pH.

Pharmacological properties

Pharmacodynamic parameters.
The active pharmaceutical ingredients of the combined drug terzhinan have a multifaceted local therapeutic effect during the inflammatory process in the vaginal mucosa of various etiologies, maintaining its integrity and the physiological range of pH values ​​of the vaginal environment. The aminoglycoside antibiotic neomycin binds to the 30S subunit of the bacterial ribosome, causing the bacterium to be unable to synthesize proteins vital for its growth. Neomycin also inhibits bacterial DNA polymerase. Neomycin is active against pyogenic vaginal microflora. Also sensitive to nystatin are Brahamella catarrhalis and Haemophilus influenzae, acinetobacter, corynebacterium, listeriosis pathogens, methicillin-sensitive staphylococcus, bacteria of the genera Citrobacter (C. freundii, C. koseri), Enterobacter, Campylobacter, Escherichia coli, Klebsiella, Morganella, Proteus (P. mirabilis, P. vulgaris), Serracia, Providencia rettgeri, Salmonella, Shigella, Yersinia and Pasteurella.

A representative of the group of 5-nitroimidazoles, ternidazole has a bactericidal effect aimed at microorganisms capable of reducing the nitro group. Under the influence of the reduced form of ternidazole, the processes of DNA and protein synthesis of the microorganism are disrupted, and the processes of cellular respiration are inhibited. Ternidazole is active against anaerobes (including Gardnerella vaginalis) and Trichomonas vaginalis.

The polyene antifungal drug nystatin has both fungistatic and fungicidal effects in vitro against a wide range of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata. Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to ergosterols in the cell membrane of susceptible species, which leads to a change in its permeability and subsequent loss of potassium, as well as other intracellular components and, ultimately, the death of the microorganism.

Prednisolone is a synthetic corticosteroid used as an anti-inflammatory agent. Prednisolone inhibits leukocyte infiltration at the site of inflammation, interferes with the effects of mediators of the inflammatory response, and suppresses the humoral immune response. The anti-inflammatory effect of GCS is associated with lipocortin proteins that inhibit phospholipase A2, which control the biosynthesis of such powerful inflammatory mediators as prostaglandins and leukotrienes. Prednisolone reduces the severity of the inflammatory response by limiting capillary dilatation and vascular permeability. Prednisolone is a GCS receptor agonist: the GCS receptor-ligand complex is translocated into the cell nucleus, where it binds to glucocorticoid response elements in the promoter region of target genes. The DNA-bound receptor then interacts with key transcription factors to cause increased or decreased expression of specific target genes, including suppression of interleukin 2 expression.

Pharmacokinetic parameters. Not explored.

Tips for using the drug during lactation

If the possible risks for the woman are higher than the possible risks for the baby, then you should stop breastfeeding for a while.

Expressing while using suppositories will minimize possible consequences for the baby. After completing the course of treatment with Terzhinan, breastfeeding can be continued. Thus, lactation can be maintained by this action. You just need to remember to do this so as not to reduce milk production.

According to the instructions for use, terzhinan suppositories are used once a day. You can feed your child immediately before taking this remedy. It's better to do this at night. If the child wakes up, then feed him with formula. The half-life of terzhinan is 4 hours. Therefore, after 8 hours the medicine will be completely eliminated from the body. Breast milk will no longer contain terginan and it is safe to continue breastfeeding.

Treatment should be carried out together with a partner so as not to fear the recurrence of such problems.

You should not self-diagnose and prescribe Terzhinan. Sometimes completely different diseases can have similar symptoms. Accordingly, the appointments will be different.

Suppositories have much less systemic effect than tablet forms. Therefore, when breastfeeding, it is worth using medications for local use.

A breastfeeding woman should consult a specialist before taking any medication.

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Safe alternatives to terzhinan

There are safe analogues. The following medications are most effective:

• Pimafucin . Available in different forms: tablets, suppositories, creams. May be in tablet or cream form. It is a monocomponent drug.
• Diflucan . A single dose of the capsule is sufficient for a course of treatment of thrush. Used for the treatment of local and generalized candidiasis and vaginitis.
• Flucostat . Release form: capsules for oral administration. Can be used for urogenital fungal diseases in women.
• Fluconazole . There are forms for internal and intravenous administration. Quickly eliminates the symptoms of fungal infection. Reduces inflammation of the vaginal mucosa
• Clotrimazole . The cheapest drug of all listed. Sold in the form of suppositories or ointments. Its main purpose is to treat thrush. Unlike terzhinan, it does not act on sexually transmitted infections

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Despite the variety of medications, only a doctor can prescribe them correctly. Before nursing mothers take tablets or capsules, it is necessary to consult a specialist.

Is it possible to use terzhinan during gw?

There are no contraindications to this medicine during pregnancy and lactation. If you need to take terzhinan while breastfeeding, you need to assess all the risks and consult a gynecologist. Since suppositories are intended for topical use, it must be remembered that their absorption into the systemic circulation is low. Consequently, breast milk will contain only a minimal amount of the active ingredient.

When feeding a newborn baby, the use of terzhinan suppositories usually does not interfere with breastfeeding.

During lactation, when treating a nursing woman, you need to carefully monitor the child's reaction. If a breastfed baby experiences any unusual symptoms, treatment should be stopped. These include: anxiety, refusal to eat, poor sleep. Then, after stopping Terzhinan, you need to find out the reason for this behavior of the child.

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Usually, 10 days of treatment is enough to treat common vaginitis.

For severe infections, it is possible to extend terzhinan for up to 20 days.

Terzhinan is prescribed for prophylactic purposes in a short course of 5 to 6 days. For example, before gynecological surgery or diagnostic procedures.

During lactation, the health and treatment of a nursing woman should be given special attention. The baby's health depends on this.

If a fungal infection is detected, its treatment should not be neglected. Candidiasis is caused by special yeast-like fungi. In a woman who is breastfeeding, these pathogenic microorganisms can enter the bloodstream. From the blood they pass into breast milk. Your baby may develop oral thrush.

The use of terzhinan is actively used in pregnant and lactating women. Sometimes it is prescribed immediately after childbirth to prevent secondary infection.